Mireille and Kirika kill a leading member of the Cosa Nostra. To deal with Noir, the Mafia summon Lady Silvana Greone, the "Intoccabile", from Sicily. Silvana sets a trap at a cottage in a forest, where she awaits Noir with three of Sicily's best killers, known as "The Three Mafia Saints". Kirika fights two of them, Paolo and Dominic, outside. Mireille enters the cottage, where she kills the third one, Francesco. However, she is unable to fight Silvana, whom she has feared ever since they first met as young girls.