Maria Ōsawa and Minoru Minorikawa are dispatched to Shanghai from Japan, two years after the events of 428: Shibuya Scramble, to cover the upcoming International Anti-Terrorism Conference in the city with various world leaders coming to attend the meeting. Canaan, a Middle Eastern teenaged mercenary, was in the city as well after meeting with the unknown female contact with information that her rival Alphard Al Sheya was captured and secretly detained in Karachi, Pakistan by covert operators of the CIA's Special Activities Division. When Maria comes to see an unknown man dead with the Ua virus, Canaan saves her from being assassinated by masked gunmen before she defeats the rest of them without alerting and panicking the public with heightened senses in synesthesia. Meanwhile, the CIA's SAD convoy comes under attack from an IED ambush while transporting Alphard in their custody.