In a small town in Italy, Tenma and his best friend Alone are living in peace at an orphanage. Alone is an aspiring painter and visits the cathedral where he hears about a painting that is so beautiful it is said to redeem souls. While painting in a meadow, Alone is approached by Pandora. She tells him that he is the purest human soul and therefore he will one day be the vessel of Hades, King of the Underworld. After a flood threatens his home village, Tenma awakens his cosmos in order to reroute the flood's path...