The American government hires Golgo 13 to eliminate a Syndicate-established hideout where poisons from various animals are weaponized by the CIA for various black ops operations. However, another assassin named AX-3 is also hired out by the American government to do the same thing Golgo was supposed to do. AX-3 is eventually killed in a shootout between the two assassins when his handler informs him of his orders to eliminate Golgo 13.