In Orth, Kiyui falls ill to a mysterious plague known as the Birthday-Death Disease, rumored to affect citizens on their birthdays. Jiruo takes Kiyui to the Caravan Fleet, a boat anchored in the bay surrounding the Abyss, for medical treatment. When Kiyui's symptoms suddenly disappear, pharmacist Mio muses that it reminded her of the bizarre Curse of the Abyss...