Ryoan assists at Kouan Ogata's smallpox vaccination clinic, but they have a difficult time convincing the general population that the process is safe. When they visit Zen'emon Ninaya, a sick shop owner, he refuses to be vaccinated which risks his family, staff and customers with the smallpox infection. Ryoan tracks down others who may be infected and gets beaten up by an infected yakuza named Heita after suggesting he should be vaccinated...