Black Jack prepared to return to Japan with Pinoko when he is requested to go to the Sky Hospital. Jack finds the only patient is Zen Mantoku, who suffers from the Phoenix disease because he and the other members of the Noir Project were injected with B.O.P. Jack agrees to assist Dr. White for 1¥ billion to develop a cure. However, Renka, aggrieved by the loss of her husband and daughter, and fact that Black Jack gave her the face of her husband's former wife, secretly plots to kill Jack and obtain the vaccine so she can make a fortune from spreading the Phoenix disease...