Three years ago, Sam said farewell to his life as a hunter with his brother, Dean, and his father, John, and went to a university to study law. There he met a girl named Jessica, who would later become his girlfriend. During that time, a mysterious incident happens to two of Jessica's friends: they die after bleeding from their eyes. The demon's hand draw's near Jessica's back, too. Meanwhile, as hunters, Dean and John are investigating the same incident.